Other forms of botox
Use of botox for the treatment of overactive bladder in such patients and in patients with multiple recurrent utis during treatment should only be considered when the benefit is likely to outweigh the potential risk. Due to the risk of urinary retention, treat only patients who are willing and able to initiate catheterization post-treatment, if required, for urinary retention. In patients who are not catheterizing, post-void residual (PVR) urine volume should be assessed within 2 weeks post-treatment and periodically as medically appropriate up to 12 weeks, particularly in patients with multiple sclerosis or diabetes mellitus. Depending on patient symptoms, institute catheterization if pvr urine volume exceeds 200 mL and continue until pvr falls below 200. Instruct patients to contact their physician if they experience difficulty in voiding as catheterization may be required. Overactive bladder, in clinical trials,.5 of patients (36/552) initiated clean intermittent catheterization for urinary retention following treatment with botox 100 Units as compared.4 of patients (2/542) treated with placebo. The median duration of catheterization for patients treated with botox 100 Units was 63 days (minimum 1 day to maximum 214 days) as compared to a median duration 11 days (minimum 3 days to maximum 18 days) for patients receiving placebo.
Patients with compromised respiratory status treated with botox for white spasticity or detrusor overactivity associated with a neurologic condition should be monitored closely. Reduced blinking from botox injection of the orbicularis muscle can lead to corneal exposure, persistent epithelial defect, and corneal ulceration, especially in patients with vii nerve disorders. During the administration of botox for the treatment of strabismus, retrobulbar hemorrhages sufficient to compromise retinal circulation have occurred. It is recommended that appropriate instruments to decompress the orbit be accessible. Bronchitis was reported more frequently as an adverse reaction in patients treated for upper limb spasticity with botox (3 at 251 Units to 360 Units total dose) compared to placebo (1). In patients with reduced lung function treated for upper limb spasticity, upper respiratory tract infections were also reported more frequently as adverse reactions in patients treated with botox (11 at 360 Units total dose; 8 at 240 Units total dose) compared to placebo (6). In adult patients treated for lower limb spasticity, upper respiratory tract infections were reported more frequently as an adverse event in patients treated with botox (2 at 300 Units to 400 Units total dose compared to placebo (1). Autonomic dysreflexia associated with intradetrusor injections of botox could occur in patients treated for detrusor overactivity associated with a neurologic condition and may require prompt medical therapy. In clinical trials, the incidence of autonomic dysreflexia was greater in patients treated with botox 200 Units compared with placebo (1.5 versus.4, respectively). Botox increases the incidence of urinary tract infection. Clinical trials for overactive bladder excluded patients with more than 2 utis in the past 6 months and those taking antibiotics chronically due to recurrent utis.
botox should be discontinued and appropriate medical therapy immediately instituted. One fatal case of anaphylaxis has been reported in which lidocaine was used as the diluent, and consequently the causal agent cannot be reliably determined. Individuals with peripheral motor neuropathic diseases, amyotrophic lateral sclerosis (als or neuromuscular junction disorders (eg, myasthenia gravis or Lambert-Eaton syndrome) should be monitored when given botulinum toxin. Patients with known or unrecognized neuromuscular disorders or neuromuscular junction disorders may be at increased risk of clinically significant effects including generalized muscle weakness, diplopia, ptosis, dysphonia, dysarthria, severe dysphagia, and respiratory compromise from therapeutic doses of botox (see. Warnings and Precautions ). Treatment with botox and other botulinum toxin products can result in swallowing or breathing difficulties. Patients with pre-existing swallowing or breathing difficulties may be more susceptible to these complications. In most cases, this is a consequence of weakening of muscles in the area of injection that are involved in breathing or oropharyngeal muscles that control swallowing or breathing (see.
Botox - parkinson's Institute and Clinical Center
Intradetrusor injection of botox is also contraindicated in patients with urinary retention and in patients with post-void residual (PVR) urine volume 200 mL, who are not routinely performing clean intermittent self-catheterization (CIC). Lack of Interchangeability between Botulinum Toxin Products. The potency Units of botox are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of botox cannot be compared to nor converted into Units of any other botulinum toxin products assessed with any other specific assay method. No definitive serious adverse event reports of distant spread of toxin effect associated with botox for ziekte blepharospasm at the recommended dose (30 Units and below severe primary axillary hyperhidrosis at the recommended dose (100 Units strabismus, or for chronic migraine at the labeled doses have. Serious adverse reactions, including excessive weakness, dysphagia, and aspiration pneumonia, with some adverse reactions associated with fatal outcomes, have been reported in patients who received botox injections for unapproved uses. In these cases, the adverse reactions were not necessarily related to distant spread of toxin, but may have resulted from the administration of botox to the site of injection and/or adjacent structures. In several of the cases, patients had pre-existing dysphagia or other significant disabilities. There is insufficient information to identify factors associated with an increased risk for adverse reactions associated with the unapproved uses of botox.
Botox, injections: Side Effects, risk warning
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Botox interact with other drugs?
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Botulinum toxin - wikipedia
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What other drugs will affect, botox?
Warning: distant spread of toxin effect. Postmarketing reports indicate that the effects of botox and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These may include asthenia, generalized muscle weakness, diplopia, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening, and there have been reports of death. The risk glasvezel of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have an underlying condition that would predispose them to these symptoms. In unapproved uses, including spasticity in children, and in approved indications, cases of spread of effect have been reported at doses comparable to those used to treat cervical dystonia and spasticity and at lower doses. Botox is contraindicated in the presence of infection at the proposed injection site(s) and in individuals with known hypersensitivity to any botulinum toxin preparation or to any of the components in the formulation. Intradetrusor injection of botox is contraindicated in patients with overactive bladder or detrusor overactivity associated with a neurologic condition who have a urinary tract infection (UTI).